A Combined N-terminomics and Shotgun Proteomics Approach to Investigate the Responses of Human Cells to Rapamycin and Zinc at the Mitochondrial Level期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A Combined N-terminomics and Shotgun Proteomics Approach to Investigate the Responses of Human Cells to Rapamycin and Zinc at the Mitochondrial Level

Institution:	From the 3Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg, CNRS, IPHC UMR 7178, 67000 Strasbourg, France;;4Chemistry and Biology of Metals, Univ. Grenoble Alpes, CNRS UMR5249, CEA, BIG-LCBM, 38000 Grenoble, France

Abstract:	Download : Download high-res image (83KB) Download : Download full-size image Highlights ?Rapamycin and zinc induce moderate but significant mitochondrial proteome changes. ?The mitochondrial proteins processing system is robust under subtoxic conditions. ?Rapamycin and zinc perturb the mitochondrial proteins processing system. ?Rapamycin and zinc perturb the mitochondrial proteins homeostasis.

Keywords:	Mitochondria function or biology Cell biology* Mass Spectrometry Cellular organelles* Enzymes* N-terminomics rapamycin zinc
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