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Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

Institution:	3. Institute for Research in Immunology and Cancer, Université de Montréal, C.P. 6128, Succursale centre-ville, Montréal, Québec, H3C 3J7, Canada;;4. Department of Chemistry, Université de Montréal, Quebec, H3C 3J7, Canada;;5. Department of Developmental and Cell Biology, University of California Irvine, Irvine CA 92697;;6. Department of Biochemistry, Université de Montréal, C.P. 6128, Succursale centre-ville, Montréal, Québec, H3C 3J7, Canada

Abstract:	Download : Download high-res image (137KB) Download : Download full-size image Highlights •Quantitative phosphoproteomics of cells treated with sphingolipid analogs or PP2A inhibitor identify novel protein targets of PP2A. •PP2A substrates include several nutrient transporter proteins, GTPase regulators and proteins associated with actin cytoskeletal remodeling. •Differential regulation of Akt and Gsk3b account for the difference in vacuolating phenotype observed between SH-BC-893 and C2-ceramide. •Dynamic phosphoproteomics enabled the correlation of cell signaling with phenotypes to rationalize their mode of action.

Keywords:	Phosphoproteome Phosphorylation Quantification Cancer Biology* Cell biology*
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