Inhibition of herpesvirus-6B RNA replication by short interference RNAs |
| |
Authors: | Yoon Jong-Sub Kim Sun-Hwa Shin Min-Chu Hong Seong-Karp Jung Yong-Tae Khang In-Gu Shin Wan-Shik Kim Chun-Choo Paik Soon-Young |
| |
Institution: | Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. |
| |
Abstract: | RNA interference (RNAi) is a process of sequence-specific gene silencing, which is initiated by double-stranded RNA (dsRNA). RNAi may also serve as an antiviral system in vertebrates. This study describes the inhibition of herpesvirus-6B (HHV-6B) replication by short interference RNAs (siRNAs) that are targeted to the U38 sequence that encodes DNA polymerase. When virus-infected SupT1 cells were treated by siRNA, these cells blocked the cytopathic effect (CPE) and detected the HHV-6B antibody-negative in indirect immunofluorescence assays (IFA). Our result suggests that RNAi can efficiently block Herpesvirus-6B replication. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|