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Altered frequency of initiation sites of DNA replication in Werner's syndrome cells |
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| Authors: | Fujio Takeuchi Fumio Hanaoka Makoto Goto Ieo Akaoka Tada-aki Hori Masa-atsu Yamada Terumasa Miyamoto |
| Institution: | (1) Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 113 Hongo, Tokyo, Japan;(2) Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, 113 Hongo, Tokyo, Japan;(3) 2nd Department of Internal Medicine, Faculty of Medicine, University of Teikyo, 173 Itabashi, Tokyo, Japan;(4) Division of Genetics, National Institute of Radiological Sciences, Anagawa, 260 Chiba, Japan |
| Abstract: | Summary DNA replication of cultured fibroblasts of early passage derived from Werner's syndrome (adult progeria) patients and from normal subjects were compared by DNA fiber autoradiography. The frequency of replication initiation was decreased in Werner's syndrome cells derived from five patients compared with that in normal cells derived from three persons of different ages. The rate of DNA chain elongation did not differ between Werner's syndrome cells and normal cells. |
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