Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines |
| |
| Authors: | Guangtong Chen Xue Yang Xuguang Zhai Min Yang |
| |
| Institution: | 1. School of Medicine, Nantong University, Nantong, 226001, People’s Republic of China
2. National Engineering Laboratory for TCM Standardization Technology, Shanghai Research Center for TCM Modernization, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People’s Republic of China
|
| |
| Abstract: | Seven hydroxylates of 20(S)-protopanaxatriol (1) transformed by Absidia corymbifera AS 3.3387 were isolated and identified by spectral methods including 2D-NMR. Among them, 7β-hydroxyl-20(S)-protopanaxatriol (2), 7α-hydroxyl-20(S)-protopanaxatriol (3), and 7β, 15α-dihydroxyl-20(S)-protopanaxatriol (7) are new compounds. The metabolites 2, 6, 7, and 8 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
