Surface Thermodynamics of Mucoadhesive Dry Powder Formulation
of Zolmitriptan |
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Authors: | Amjad Alhalaweh Annamaria Vilinska Elisabetta Gavini Giovanna Rassu Sitaram P Velaga |
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Institution: | .Department of Health Sciences, Luleå University of Technology, 971 87 Luleå, Sweden ;.Department of Chemical Engineering and Geosciences, Luleå University of Technology, Luleå, 971 87 Sweden ;.Department of Drug Sciences, University of Sassari, Sassari, via Muroni 23, 07100 Sassari, Italy |
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Abstract: | Microparticle powders for nasal delivery were formulated to contain the model drug, zolmitriptan, and varying proportions
of different polymers. The objective of the study was to investigate the effects of these formulative parameters on the surface
chemistry of the spray-dried microparticles and their potential for adhesion to the tested substrates, porcine mucin, and
nasal tissue. The polymers used were chitosans of varying ionization states and molecular weights and hydroxypropyl methyl
cellulose. The surface energies of the surfaces of the microparticles were determined using contact angle measurements and
the van Oss model. The theory of surface thermodynamics was applied to determine the theoretical potential for the different
materials to adhere to the substrates. It was found that the drug or polymers alone, as well as the various formulations,
were more likely to adhere to mucin than to nasal tissue. Further, there was a trend for higher molecular weight chitosans
to adhere better to the substrates than lower molecular weight chitosans. Similarly, adhesion was improved for formulations
with a higher content of polymers. These theoretical predictions may be compared with further experimental results and be
of use in making informed decisions on the choice of formulations for future expensive bio-studies. |
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