Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an <Emphasis Type="Italic">in vitro</Emphasis>study |
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| Authors: | Kristin Andreas Carsten Lübke Thomas Häupl Tilo Dehne Lars Morawietz Jochen Ringe Christian Kaps Michael Sittinger |
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| Institution: | 1.Tissue Engineering Laboratory and Berlin – Brandenburg Center for Regenerative Therapies, Department of Rheumatology,Charité – Universit?tsmedizin Berlin,Berlin,Germany;2.Tissue Engineering Laboratory, Department of Rheumatology,Charité – Universit?tsmedizin Berlin,Berlin,Germany;3.Institute for Pathology,Charité – Universit?tsmedizin Berlin,Berlin,Germany;4.TransTissueTechnologies GmbH,Berlin,Germany |
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| Abstract: | Background Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic autoimmune disease that leads to progressive cartilage destruction.
Advances in the treatment of RA-related destruction of cartilage require profound insights into the molecular mechanisms involved
in cartilage degradation. Until now, comprehensive data about the molecular RA-related dysfunction of chondrocytes have been
limited. Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes. |
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