The genes for human gastrin and cholecystokinin are located on different chromosomes |
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| Authors: | T. Lund A. H. M. Geurts van Kessel S. Haun J. E. Dixon |
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| Affiliation: | (1) Iniversity Department of Clinical Chemistry 6321, Rigshospitalet, DK-2100 Copenhagen, Denmark;(2) Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands;(3) Department of Biochemistry, Purdue University, 47907 West Lafayette, IN, USA |
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| Abstract: | Summary The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q. |
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