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IRAK-4 inhibitors. Part 1: a series of amides |
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| Authors: | Buckley George M Gowers Lewis Higueruelo Alicia Perez Jenkins Kerry Mack Stephen R Morgan Trevor Parry David M Pitt William R Rausch Oliver Richard Marianna D Sabin Verity Fraser Joanne L |
| Institution: | UCB, Department of Medicinal Chemistry, Granta Park, Great Abington, Cambridge, CB21 6GS, UK. |
| Abstract: | The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo. |
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