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Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells |
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| Authors: | Saeyoung Park Mina Lee Hosoon Lee Hae-Yeong Kim Yun-Sil Lee Shinwu Jeong Doo-il Jeoung |
| Affiliation: | (1) Division of Functional Genomics, In2Gen Company, 28, Yongon-dong, Chongno-gu, Seoul, 110-799, Korea;(2) Institute of Life Sciences and Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon, 449-701, Korea;(3) Laboratory of Radiation Effects, Korea Cancer Center Hospital, 215-4, Gongneung-Dong, Nowon-Gu, Seoul, 139-706, Korea;(4) LGCI Life Science R&D, 104-1 Moonji-Dong, Yuseong-Gu, Daejeon, 305-830, Korea |
| Abstract: | A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells. |
| Keywords: | cDNA microarray 5-fluorouracil gastric cancer cells signature genes |
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