Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463 |
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Authors: | Wu H Zhang S Qiu W Zhang G Xia Q Xiao C Huang X Huang M Agen P Fan T Yang J Milunsky A |
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Institution: | Department of Medical Genetics, First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, PR China. |
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Abstract: | A novel human KRAB (Krüppel associated box) type zinc finger protein encoding gene, ZNF463, was obtained by mRNA differential display and RACE. It consists of 1904 nucleotides and encodes a protein of 463 amino acids with an amino-terminal KRAB domain and 12 carboxy-terminal C2H2 zinc finger units. The gene is mapped to chromosome 19q13.3 approximately 4 by FISH. As from Northern blot analysis ZNF463 is only expressed in testis, RT-PCR indicates that ZNF463 is expressed more highly in normal fertile adults than in fetus and azoospermic patients suggesting that it may play a role in human spermatogenesis. |
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