Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line |
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Authors: | Russo M Palumbo R Tedesco I Mazzarella G Russo P Iacomino G Russo G L |
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Institution: | Institute of Food Science and Technology, Avellino, Italy. |
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Abstract: | Several malignant cell lines are resistant to CD95-(Apo1/Fas)-mediated apoptosis, even when the CD95 receptor is highly expressed. Sensitivity to CD95-induced apoptosis can be restored using different molecules. In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti-CD95 monoclonal antibody, increases DNA fragmentation and caspase-3 activity in HPB-ALL cells. These cells have been selected for their known resistance to CD95-induced apoptosis. At molecular level, quercetin lowers the level of intracellular reactive oxygen species, reduces mitochondrial transmembrane potential, thereby leaving the expression of CD95 receptor unchanged. |
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