Importance of inlet air velocity in fluid bed dyring of a granulation prepared in a high shear granulator |
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Authors: | Julia ZH Gao David B. Gray Rajeshwar Motheram Munir A. Hussain |
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Affiliation: | (1) Pharmaceutical Research and Development, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80400, 19880-0400 Wilmington, DE |
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Abstract: | Conclusions This report shows that inlet air velocity can play a critical role in maintaining proper fluidization and, ultimately, uniform
drying. The mechanism by which air velocity affects fluidization has been discussed by various researchers [4–5]. An indication
of good fluidization is a free downward flow of the granules at the sight glass of the drying bowl, but such limited observation
could be misleading. In such cases, the exhaust air temperature can be used to detect poor fluidization. If the exhaust air
temperature rises more rapidly than anticipated, as seen with process 1 (Figure 1), it is an indication that fluidization
is incomplete.
In conclusion, a fundamental understanding of the mechanism of fluidization by inlet air will help in the development of a
fluid bed drying process that produces uniformly dried granules and minimizes the number of process problems encountered. |
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Keywords: | Inlet Air Velocity Fluid Bed Drying Drying Uniformity Sample Locations |
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