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Importance of inlet air velocity in fluid bed dyring of a granulation prepared in a high shear granulator
Authors:Julia ZH Gao  David B. Gray  Rajeshwar Motheram  Munir A. Hussain
Affiliation:(1) Pharmaceutical Research and Development, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80400, 19880-0400 Wilmington, DE
Abstract:Conclusions  This report shows that inlet air velocity can play a critical role in maintaining proper fluidization and, ultimately, uniform drying. The mechanism by which air velocity affects fluidization has been discussed by various researchers [4–5]. An indication of good fluidization is a free downward flow of the granules at the sight glass of the drying bowl, but such limited observation could be misleading. In such cases, the exhaust air temperature can be used to detect poor fluidization. If the exhaust air temperature rises more rapidly than anticipated, as seen with process 1 (Figure 1), it is an indication that fluidization is incomplete. In conclusion, a fundamental understanding of the mechanism of fluidization by inlet air will help in the development of a fluid bed drying process that produces uniformly dried granules and minimizes the number of process problems encountered.
Keywords:Inlet Air Velocity  Fluid Bed Drying  Drying Uniformity  Sample Locations
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