7,8-secolignans from Schisandra wilsoniana and their anti-HIV-1 activities |
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| Authors: | Zhang Xing-Jie Yang Guang-Yu Wang Rui-Rui Pu Jian-Xin Sun Han-Dong Xiao Wei-Lie Zheng Yong-Tang |
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| Institution: | 1. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.?R. China (phone: +86‐871‐5195684;2. fax: +86‐871‐5195684);3. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P.?R. China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China, (+86‐871‐5223256;5. fax: 86‐871‐5216343) |
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| Abstract: | Two new 7,8‐secolignans, marphenols A and B ( 1 and 2 , resp.), together with a known related derivative, 7,8‐secoholostylone B ( 3 ), were isolated from the stems of Schisandra wilsoniana. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR techniques. The anti‐HIV‐1 activities of 1 – 3 were evaluated. Compound 1 inhibited HIV‐1IIIB‐induced syncytia formation with an EC50 value of 0.55 μg ml?1. It reduced p24 antigen expression in acutely HIV‐1IIIB‐infected C8166 cells and primary isolate HIV‐1TC‐2‐infected peripheral blood mononuclear cells (PBMCs), with EC50 values of 3.34 and 0.52 μg ml?1, respectively. It showed no effects on the HIV‐1IIIB replication in chronically infected H9 cells as well as fusion inhibition. |
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| Keywords: | Schisandra wilsoniana 7 8‐Secolignans Marphenols A and B 7 8‐Secoholostylone B Anti‐HIV‐1 activity HIV |
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