The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells |
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| Authors: | M Nogami M Suko T Miyamoto |
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| Affiliation: | Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan. |
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| Abstract: | C16- and C18- platelet-activating factor (PAF) at 10(-6) M enhanced the uptake of [14C]aminopyrine (AP) by isolated guinea pig parietal cells. This increase was inhibited by a PAF antagonist CV-6209. In a medium with a low calcium (Ca2+) concentration (2 uM), this increase was not observed, which indicates that the increase of AP uptake by PAF is dependent on extracellular Ca2+. PAF and lyso-PAF showed no effect on AP uptake in the presence of histamine or carbachol. |
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