Bio-resolution of glycidyl (o, m, p)-methylphenyl ethers by Bacillus megaterium |
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| Authors: | Zhengfang Zhang Yanming Sheng Keyi Jiang Zhao Wang Yuguo Zheng Qing Zhu |
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| Affiliation: | (1) College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310014, People’s Republic of China; |
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| Abstract: | A newly isolated Bacillus megaterium with epoxide hydrolase activity resolved racemic glycidyl (o, m, p)-methylphenyl ethers to give enantiopure epoxides in 84–99% enantiomeric excess and with 21–73 enantiomeric ratios. The (S)-enantiomer was obtained from rac-glycidyl (o or m)-methylphenyl ether while the (R)-epoxides was obtained from glycidyl p-methylphenyl ether. The observations are explained at the level by enzyme-substrate docking studies. |
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