The Nucleotide Sequence of Human Acylamino Acid-Releasing Enzyme |
| |
Authors: | Mitta Masanori; Ohnogi Hiroshi; Mizutani Shigetoshi; Sakiyama Fumio; Kato Ikunoshin; Tsunasawa Susumu |
| |
Institution: | 1Biotechnology Research Laboratories, Takara Shuzo Co., Ltd. Seta, Otsu, 520-21, Japan
2Institute for Protein Research, Osaka University Suita, Osaka 565, Japan |
| |
Abstract: | The nucleotide sequence of a cDNA coding for the human acylaminoacid-releasing enzyme (AARE, also known as acylpeptide hydrolase)EC 3.4.19.1] subunit has been determined. The amino acid sequenceof human AARE subunit deduced from its cDNA nucleotide sequenceshowed a high degree of identity (91.5%) with both the correspondingproteins from the pig and the rat. The AARE cDNA shows 99.2%identity with a 3.3 kb cDNA transcribed from a locus (DNF15S2)on the short arm of human chromosome 3, whose deletion is associatedwith small cell lung cancer, taking into consideration thatthe sequence of the 3.3-kb cDNA previously reported was causedby misreading. |
| |
Keywords: | Acylamino Acid-Releasing Enzyme cDNA sequence N-teminal acetylation Small cell lung cancer |
本文献已被 Oxford 等数据库收录! |
|