Quorum sensing inhibitors as antipathogens: biotechnological applications |
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Authors: | Vipin Chandra Kalia Sanjay KS Patel Yun Chan Kang Jung-Kul Lee |
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Institution: | 1. Department of Chemical Engineering, Konkuk University, Seoul 05029, Republic of Korea;2. Department of Materials Science and Engineering, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 02841, Republic of Korea |
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Abstract: | The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through QS regulation. The major issue to arise from such networks is increased bacterial resistance to antibiotics, resulting from QS-dependent mediation of the formation of biofilm, the induction of efflux pumps, and the production of antibiotics. QS inhibitors (QSIs) of diverse origins have been shown to act as potential antipathogens. In this review, we focus on the use of QSIs to counter diseases in humans as well as plants and animals of economic importance. We also discuss the challenges encountered in the potential applications of QSIs. |
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Keywords: | Antipathogens Aquaculture Biofilm Human health Infectious diseases Inhibitors Pathogens Quorum sensing AHL Acylhomoserine lactone AI Autoinducer AIP Autoinducing peptide DSF Diffusible signal factor HSL Homoserine lactone MBR Membrane bioreactor MIC Minimum inhibitory concentration PHAs Polyhydroxyalkanoates PQS QS Quorum sensing QSI Quorum sensing inhibitor QSS Quorum sensing system C4HSL C6HSL C7HSL C8HSL C12HSL OHC6HSL 3OC6HSL 3OC8HSL 3OC10HSL 3OC12HSL Corresponding authors |
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