The effect of short chain fatty acids on transmural electrical potential across rat small intestine in vivo |
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| Authors: | Malcolm J. Wall Richard J. Declusin Konrad H. Soergel R.David Baker |
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| Affiliation: | 1. Clinical Physiology Section, Department of Physiology, The medical College of Wisconsin, Milwaukee, Wisc. USA;2. Department of Medicine, The medical College of Wisconsin, Milwaukee, Wisc. USA;3. Research Service, Veterans Administration Center, Wood Milwaukee, Wisc. USA;4. Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas U.S.A. |
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| Abstract: | Short chain fatty acids suddenly produce a phasic increase in transmural electrical potential difference (PD) when placed in the lumen of rat small intestine in vivo. With concentrations of propionate ranging fro 50μM to 1000 μM the amplitude of the response in jejunum is about 5.5 mV. The concentration giving half this effect is about 20 μM. With 10 mM propionate the duration of the response is 3–5 min; after this, PD again equals the control value and the gut is refractory to further additions. Removing propionate from the mucosal surface produces no change in PD, but does restore responsiveness to subsequent exposure to short chain fatty acids.This effect is indpendent of a variety of other alterations in PD such as those caused by sugars, amino acids, bile salts, theophylline, prostaglandins, and ATP. Mechanism and significance of this surprisingly sensitive response remain obscure. |
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| Keywords: | To whom reprint requests should be addressed (Galveston). |
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