Effect of glucocorticoids on fetoprotein production by an established cell line from Morris hepatoma 8994 |
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Authors: | Beatrice de Nechaud Joyce E Becker Van R Potter |
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Institution: | McArdle Laboratory for Cancer Research, Madison, Wisconsin 53706, U.S.A. |
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Abstract: | Glucocorticoids at concentrations equal to or higher than 10?7M lead to an increase of alpha-fetoprotein production by an established cell line from Morris hepatoma 8994. These cells also secreted alphaM-fetoprotein into the culture medium but only after addition of at least 4×10?7M hydrocortisone or 5×10?8M dexamethasone. The effects on both fetoproteins were observed in spite of a decrease of cell multiplication and an increase of cell detachment. |
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