Cell source,differentiation, functional stimulation,and potential application of human thermogenic adipocytes in vitro |
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| Authors: | Dinh-Toi Chu Yang Tao Le Hoang Son Duc-Hau Le |
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| Affiliation: | 1.Institute for Research and Development,Duy Tan University,Da Nang,Vietnam;2.Faculty of Biology,Hanoi National University of Education,Hanoi,Vietnam;3.College of Food Science and Technology,Nanjing Agricultural University,Nanjing,Vietnam;4.VNU University of Science,Vietnam National University,Hanoi,Vietnam;5.VINMEC Research Institute of Stem Cell and Gene Technology,Hanoi,Vietnam |
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| Abstract: | Recent investigations have showed that the functional thermogenic adipocytes are present in both infants and adult humans. Accumulating evidence suggests that the coexistence of classical and inducible brown (brite) adipocytes in humans at adulthood and these adipocytes function to generate heat from energy resulting in reducing body fat and improving glucose metabolism. Human thermogenic adipocytes can be differentiated in vitro from stem cells, cell lines, or adipose stromal vascular fraction. Pre-activated human brite adipocytes in vitro can maintain their thermogenic function in normal or obese immunodeficient mice; therefore, they improve glucose homeostasis and reduce fat mass in obese animals. These key findings have opened a new door to use in vitro thermogenic adipocytes as a cell therapy to prevent obesity and related disorders. Thus, this paper intends to highlight our knowledge in aspects of in vitro human brite/brown adipocytes for the further studies. |
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