Thymidylate synthase and methionine synthase polymorphisms are not associated with susceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran |
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Authors: | Zohreh Rahimi Zainab Ahmadian Reza Akramipour Asad Vaisi-Raygani Ziba Rahimi Abbas Parsian |
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Institution: | (1) Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;(2) Department of Biochemistry, Medical Biology Research Center, Medical School, Daneshgah Avenue, 67148-69914, Kermanshah, Iran;(3) Department of Pharmacology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran;(4) Department of Pediatrics Hematology Oncology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran;(5) Division of Neuroscience & Behavior, NIAAA, National Institutes of Health, Rockville, MD, USA |
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Abstract: | In order to determine the influence of polymorphism in thymidylate synthase (TS 28-bp repeat) and methionine synthase (MS
A2756G) genes on the susceptibility to acute lymphoblastic leukemia (ALL), 73 children with ALL and 128 age and sex matched
unrelated healthy individuals from the Kermanshah Province of Iran were screened. The genotyping of TS 28-bp repeat and MS
A2756G polymorphisms were performed by polymerase chain reaction (PCR) and PCR–RFLP, respectively. The frequency of TS 2R
allele in patients and controls were 41.5 and 38%, respectively (Odds ratios (OR) = 1.13, 95%CI 0.73–1.74, P = 0.56). The allelic frequency of G allele of MS was higher (25%) in patients compared with healthy subjects (23%) (OR = 1.09,
95%CI 0.67–1.75, P = 0.71). Considering MS AA and TS 3R3R genotypes as reference indicated that individuals with MS GG + TS 2R2R genotypes have
1.3-fold increase in the risk of ALL (OR = 1.3, 95%CI 0.6–2.7, P = 0.5). Our results showed that neither TS 28-bp repeat nor MS A2756G polymorphisms are risk factors for susceptibility to
ALL in Western Iran. |
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