Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens |
| |
| Authors: | Jose C Jimenez-Lopez Emma W Gachomo Oluwole A Ariyo Lamine Baba-Moussa Simeon O Kotchoni |
| |
| Institution: | (1) Department of Biochemistry, Cell and Molecular Biology of Plants, Estaci?n Experimental del Zaid?n, Consejo Superior de Investigaciones Cient?ficas (CSIC), Profesor Albareda 1, E-18008 Granada, Spain;(2) Department of Botany and Plant Pathology, Purdue University, Lilly Hall, 915 West State Street, West Lafayette, IN 47907, USA;(3) Department of Biology, Division of Mathematics and Natural Sciences, Allen University, Columbia, SC 29204, USA;(4) Laboratoire de Biologie et de typage Moleculaire en Microbiologie, Departement de Biochimie et Biologie Cellulaire, FAST, Universite D’Abomey-Calavi, 05BP1604 Cotonou, Benin;(5) Department of Agronomy, Purdue University, Lilly Hall, 915 West State Street, West Lafayette, IN 47907, USA;(6) Present address: Department of Biological Sciences, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA; |
| |
| Abstract: | Selected members of plant pathogenesis-related and seed storage proteins represent specific groups of proteins with potential
characteristics of allergens. Efforts to understand the mechanism by which pathogenesis-related proteins mediate a broad cross-reactivity
in pollen-plant food allergens are still limited. In this study, computational biology approach was used to reveal specific
structural implications and conservation of different epitopes from members of Bet v 1 and nsLTP protein families mediating
cross-reactivity between pollen and food (fruits, vegetables, legumes, and nut/seeds) allergens. A commonly shared epitope
conservation was found among all pollen and food Bet v 1 and nsLTP protein families, respectively. However, other allergenic
epitopes were also specifically detected in each family. The implication of these conserved epitopes in a broad cross-reactivity
for allergy clinical trials is here discussed. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
