MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer |
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| Authors: | Hao Jun Zhang Shuyu Zhou Yingqi Liu Cong Hu Xiangui Shao Chenghao |
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| Institution: | aDepartment of Biochemistry and Institute for Medical Sciences, Chonbuk National University, Medical School, Jeonju, Jeonbuk 560-182, Republic of Korea;bDepartment of Surgery, Chonbuk National University, Medical School, Jeonju, Jeonbuk 560-182, Republic of Korea;cDepartment of Companion and Laboratory Animal Science, Kongju National University, Yesan 340-702, Republic of Korea;dDivision of Animal Science and Resources Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon 305-764, Republic of Korea |
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| Abstract: | Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component of oat. Previous study demonstrates that DHAvD strongly inhibits activation of nuclear factor-kappa B (NF-κB), which is a major component in cancer cell invasion. The present study investigated whether DHAvD can modulate MMP-9 expression and cell invasion in MCF-7 human breast cancer cells. MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD. DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells. The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-κB and MAPK/AP-1 pathways in MCF-7 cells. DHAvD may have potential value in breast cancer metastasis. |
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| Keywords: | DHAvD MMP-9 NF-κB AP-1 Metastasis Invasion MCF-7 |
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