| Ryanodine受体相关的肌肉疾病及其研究进展 |
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| 作者姓名： | Han HM Yin CC |
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| 作者单位： | 北京大学医学部生物物理学系,北京,100083 |
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| 基金项目： | 国家自然科学基金资助课题 (30 370 379) |
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| 摘 要： | Ryanodine受体(ryanodine receptor,RyR)是位于细胞内肌质网(sarcoplasmic reticulum,SR)膜上的钙释放通道,是骨骼肌和心肌细胞兴奋-收缩偶联过程中的关键蛋白。RyR结构和功能的改变,往往导致肌细胞兴奋-收缩的解偶联,从而引发一些相关的肌肉疾病。目前的研究肯定这些疾病的发病机制都与RyR密切相关,本文就此方面的最新研究进展进行综述,为预防和治疗这些疾病提供理论依据。
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| 关 键 词： | Ryanodine受体 Ca^2＋ 兴奋-收缩偶联 肌肉疾病 |
Progress in the study of ryanodine receptor-related muscle diseases |
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| Han HM,Yin CC.Progress in the study of ryanodine receptor-related muscle diseases[J].Progress in Physiological Sciences,2005,36(1):18-22. |
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| Authors: | Han Hong-Mei Yin Chang-Cheng |
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| Institution: | Department of Biophysics, Peking University Health Science Center, Beijing 100083. |
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| Abstract: | Ryanodine receptor (RyR), a calcium release channel within the sarcoplasmic reticulum (SR) membrane, is a key protein in skeletal and cardiac excitation-contraction coupling. The structural and functional changes of RyR can result in decoupling of excitation-contraction, and lead to muscle diseases. Current study confirms that RyR is related to the pathogenesis of these diseases. In this review, we look at the current progress in the study on RyR and these diseases to provide the molecular basis in the prevention and therapy of these diseases. |
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| Keywords: | Ryanodine receptor Ca 2 Excitation-contraction coupling Muscle disease |
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