Synthesis of 3'-ureidoadenosine analogues and their binding affinity to the A3 adenosine receptor |
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| Authors: | Chun Moon Woo Lee Hyouk Woo Kim Ae Yil Kim Myong Jung Kim Hea Ok Gao Zhan-Guo Jacobson Kenneth A Jeong Lak Shin |
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| Affiliation: | Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea. |
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| Abstract: | Novel 3'-ureidoadenosine analogues were synthesized from 1,2:5, 6-di-O-isopropylidene-D-glucose in order to lead to stronger hydrogen bonding at the A3 adenosine receptor than the corresponding 3'-aminoadenosine derivatives. However, all synthesized 3'-ureidoadenosine analogues have lost their binding affinities to the all subtypes of adenosine receptors, indicating that bulky 3'-urea moiety led to conformational distortion. |
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