Selectivity-Enhancement of Hydrolase Reactions |
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| Authors: | Kurt Faber Gianluca Ottolina Sergio Riva |
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| Affiliation: |
a Institute of Organic Chemistry, Graz University of Technology, Graz, Austria
b Istituto di Chimica degli Ormoni, C.N.R., Milano, Italy |
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| Abstract: | This review pinpoints the strategies which can be employed to improve the enantio- and diasteroselectivity of hydrolytic enzymes, i.e. esterases, proteases, and lipases. The influence of variations of reactants, — enzyme and substrate — and conditions — kinetics, medium, temperature, pH — on the chiral recognition process of the enzyme is discussed with examples from the recent literature. |
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| Keywords: | Esterase Protease Lipase Selectivity |
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