Lactobacillli expressing llama VHH fragments neutralise Lactococcusphages |
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| Authors: | Anna Hultberg Denise M Tremblay Hans de Haard Theo Verrips Sylvain Moineau Lennart Hammarström Harold Marcotte |
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| Affiliation: | 1.Division of Clinical Immunology at the Department of Laboratory Medicine,Karolinska Institutet at Karolinska University Hospital in Huddinge,Stockholm,Sweden;2.Groupe de recherche en écologie buccale, Faculté de médecine dentaire,Félix d'Hérelle Reference Center for Bacterial Viruses, Université Laval,Québec,Canada;3.Unilever Research and Development,Vlaardingen,The Netherlands;4.Cellular Architecture and Dynamics (CAD), Utrecht University,Utrecht,The Netherlands;5.Département de biochimie et de microbiologie, Faculté des sciences et de génie,Université Laval,Québec,Canada;6.Ablynx,Ghent,Belgium;7.Cellular Architecture and Dynamics (CAD),Utrecht University,The Netherlands |
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| Abstract: | Background Bacteriophages infecting lactic acid bacteria (LAB) are widely acknowledged as the main cause of milk fermentation failures. In this study, we describe the surface-expression as well as the secretion of two functional llama heavy-chain antibody fragments, one binding to the major capsid protein (MCP) and the other to the receptor-binding proteins (RBP) of the lactococcal bacteriophage p2, by lactobacilli in order to neutralise lactococcal phages. |
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