A platform for compartmentalized protein synthesis: protein translation and translocation in the ER |
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Authors: | Nicchitta Christopher V |
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Institution: | Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. c.nicchitta@cellbio.duke.edu |
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Abstract: | Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested. |
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