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Deferiprone: structural and functional modulating agent of hemoglobin fructation |
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| Authors: | Naghmeh Sattarahmady Hossein Heli Ali A. Moosavi-Movahedi K. Karimian |
| Affiliation: | 1. Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran 3. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2. Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran 4. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 5. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran 6. Arasto Pharmaceutical Chemicals Inc, Tehran, Iran |
| Abstract: | Diabetic complication arises from the presence of advanced glycation end products in different sites of the body. Great attention should be paid to recognizing anti-glycation compounds. Here, deferiprone as an oral iron chelator drug administrated in treatment of β-thalassemic patients was selected to find its effect on the fructation of hemoglobin (Hb). Our results indicated that deferiprone could prevent the AGE and carbonyl formation via inhibition of structural changes in the structure of Hb during the fructation process. Moreover, deferiprone can preserve peroxidase and esterase activities of fructated Hb similar to native Hb. Therefore, deferiprone can be introduced as an anti-glycation drug to prevent the AGE formation. |
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