T-cell priming in bone marrow: the potential for long-lasting protective anti-tumor immunity |
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Authors: | Schirrmacher Volker Feuerer Markus Fournier Philippe Ahlert Thorsten Umansky Viktor Beckhove Philipp |
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Institution: | German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. v.schirrmacher@dkfz-heidelberg.de |
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Abstract: | Circulating naïve T cells do not recognize tumor-associated antigens (TAA) directly but need to interact with dendritic cells that have had the chance to process TAA for presentation to T cells. According to recent evidence, TAA from tumor cells circulating in the blood reach the spleen and bone marrow, where resident dendritic cells can process and cross-present them to prime T cells. This in turn leads to the generation of effector and memory cells, which can either destroy tumor cells or control them in a state of tumor dormancy. For therapeutic purposes, memory T cells can be boosted by the application of tumor vaccines that express TAA, together with danger signals. Immunization of cancer patients with such a tumor vaccine has resulted in improved survival in several Phase II studies. It is proposed that such immunization leads to long-lasting protective anti-tumor memory. |
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