The antimicrobial action of low-molar-mass chitosan,chitosan derivatives and chitooligosaccharides on bifidobacteria |
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Authors: | J ?im?nek I Koppová L Filip G Tishchenko G Be??ecki |
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Institution: | (1) Technical Research Laboratory, Takanashi Milk Products Co., Ltd, Yokohama Kanagawa, 241-0023, Japan;(2) Graduate School, Science for Living System, Showa Women’s University, 1-7 Taishido, Setagaya-ku, Tokyo 154-8533, Japan; |
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Abstract: | The crude fractions of chitooligosaccharides (COS) and low-molar-mass chitosans (LMWC) were prepared by enzyme hydrolysis
of chitosan (CS). Specific growth rate of B. adolescentis, B. bifidum, B. breve, B. catenulatum, B. infantis and B. longum ssp. longum was determined in the presence of 0.025 and 0.5 % COS (<5 kDa), LMWC (5–10 kDa), and 0.025, 0.1 and 0.5 % of CS, chitosan
succinate and chitosan glutamate in vitro. Minimum inhibitory concentrations (MIC; assayed by colony counting on TPY agar plates) of COS-LMWC and CS ranged from 0.025
% to 0.75 % of CS-LMWC. The growth of all bifidobacterial strains in the presence of chitosan, its derivatives and LMWC decreased
at a concentration of 0.025 %; the bacterial growth was completely inhibited at a concentration of 0.5 %. COS did not show
any inhibitory effect, an increased growth rate was even observed in the case of B. bifidum, B. catenulatum and B. infantis. |
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