Chlorpropamide and tolbutamide inhibition of adenosine 3'5' cyclic monophosphate phosphodiesterase |
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| Authors: | G Brooker M Fichman |
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| Institution: | Departments of Medicine and Biochemistry University of Southern California School of Medicine Los Angeles, California 90033 USA |
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| Abstract: | These sulfonylurea agents inhibit the cyclic AMP phosphodiesterase, and thereby could increase the steady state level of cyclic AMP in various tissues, depending upon the tissue concentrations achieved after oral or parental administration. |
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