|
|||||
|
|
Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy |
|
| Authors: | Kim Seongjin Jiao Guan-Sheng Moayeri Mahtab Crown Devorah Cregar-Hernandez Lynne McKasson Linda Margosiak Stephen A Leppla Stephen H Johnson Alan T |
| Institution: | a PanThera Biopharma, LLC, Aiea, HI 96701, USA b Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA |
| Abstract: | New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model. |
| Keywords: | Anthrax Lethal factor Inhibitor Small molecule |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |