A human SHC-related sequence maps to chromosome 17, the SHC gene maps to chromosome 1 |
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| Authors: | Isik G Yulug Sean E Egan Chee Gee See Elizabeth M C Fisher |
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| Institution: | (1) Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, W2 1PG London, UK;(2) Division of Immunology and Cancer Research, The Hospital for Sick Children, M5G 1X8 Toronto, Ontario, Canada;(3) The Galton Laboratory, Department of Genetics and Biometry, University College, NW1 2HE London, UK |
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| Abstract: | The SHC gene encodes a protein that is thought to act as an adapter in many signal transduction pathways; the SHC protein probably facilitates the activation of RAS proteins in response to a variety of factors. We have mapped the human SHC gene and have identified a new SHC-related sequence. We have sequenced the region corresponding to the SHC 3 UTR from both loci and have mapped cosmids by fluorescence in situ hybridization. The human SHC gene maps to the proximal long arm of chromosome 1 and the SHC-related sequence maps to the proximal long arm of chromosome 17. A number of cancers have been positioned in the proximal long arm of chromosome 1; this is of interest given the oncogenic potential of the SHC protein. |
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