Growth and mycotoxin production by <Emphasis Type="Italic">Chaetomium globosum</Emphasis> |
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Authors: | Matthew R Fogle David R Douglas Cynthia A Jumper David C Straus |
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Institution: | (1) Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th Street, Mail stop 6591, Lubbock, TX 79430, USA;(2) Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, Mail stop 9410, Lubbock, TX 79430, USA |
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Abstract: | Chaetomium globosum, the most common species within this genus, produces chaetoglobosins A and C when cultured on building material. Relatively
low levels of these compounds have been shown to be lethal to various tissue culture cell lines. This study had two major
objectives: (1) to determine the frequency at which Chaetomium species are isolated in water-damaged buildings and (2) to examine the production of chaetoglobosins A and C in isolates
of C. globosum obtained from different buildings. Out of 794 water-damaged buildings, Chaetomium species were isolated in 49% of these structures. C. globosum ATCC 16021 was grown on four different media: oatmeal agar (OA), potato dextrose agar (PDA), corn meal agar (CMA), and malt
extract agar (MEA). After 4 weeks, fungal growth was evaluated based on colony diameter and the quantity of spores produced
on agar plates. In addition, production of chaetoglobosin A and C was monitored using high performance liquid chromatography.
Colony diameter, spore production, and mycotoxin production by C. globosum were the highest on OA. Out of 30 C. globosum isolates cultured on OA for 4 weeks, 16 produced detectable amounts of chaetoglobosin A and every isolate produced chaetoglobosin
C. |
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Keywords: | Chaetoglobosin Chaetomium globosum Fungus Indoor air quality Mycotoxin Sick building syndrome |
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