Roles of CUP-5, the <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis> orthologue of human TRPML1, in lysosome and gut granule biogenesis |
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Authors: | Erin M Campbell Hanna Fares |
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Institution: | (1) Department of Molecular and Cellular Biology, University of Arizona, Life Sciences South Room 531, Tucson, AZ 85721, USA |
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Abstract: | Background CUP-5 is a Transient Receptor Potential protein in C. elegans that is the orthologue of mammalian TRPML1. Loss of TRPML1 results in the lysosomal storage disorder Mucolipidosis type IV.
Loss of CUP-5 results in embryonic lethality and the accumulation of enlarged yolk granules in developing intestinal cells.
The embryonic lethality of cup-5 mutants is rescued by mutations in mrp-4, which is required for gut granule differentiation. Gut granules are intestine-specific lysosome-related organelles that
accumulate birefringent material. This link between CUP-5 and gut granules led us to determine the roles of CUP-5 in lysosome
and gut granule biogenesis in developing intestinal cells. |
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