Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction |
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Authors: | Erkan Tuncay A Aytac Seymen Evrim Tanriverdi Nazmi Yaras Berivan Tandogan N Nuray Ulusu Belma Turan |
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Institution: | (1) Department of Biophysics, School of Medicine, Ankara University, Ankara, Turkey;(2) Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey |
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Abstract: | The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3
and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences
in the responses to the intake of Ω-3E on the heart dysfunction. Experiments were performed by using Langendorff-perfused
hearts from normal, diabetic (with 50 mg/kg streptozotocin), and Ω-3E (50 mg/kg body weight/day) treated diabetic 3-month-old
Wistar rats. Ω-3E treatment of the diabetics caused small, but significant decrease (13% and 14% female versus male) in the
blood glucose level. Ω-3E treatment of the diabetic female rats did not prevent diabetes-induced decrease in left ventricular
developed pressure (LVDP) and increase in left ventricular end-diastolic pressure (LVEDP) with respect to the control female
rats. On the other hand, the treatment of diabetic male rats caused significant recovery in depressed LVDP. Furthermore, such
treatment of diabetic female and male rats caused significant recovery in depressed rates of changes of developed pressure.
This effect was more significant in males. Besides, Ω-3E caused significant further lengthening in the diabetes-induced increased
time to the peak of the developed pressure in females, while it normalized the lengthening in the relaxation of the developed
pressure in diabetic males. In addition, Ω-3E treatment caused significant restorations in the diabetes-induced altered activities
of antioxidant enzymes without any significant gender discrepancy. Present data show that there are gender related differences
in diabetic heart dysfunction and the response to antioxidant treatment. |
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Keywords: | Diabetes Oxidant stress Antioxidants Heart function n-3 Polyunsaturated fatty acids Thioredoxin reductase |
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