Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis |
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| Authors: | Koichi Murata Hiroyuki Yoshitomi Shimei Tanida Masahiro Ishikawa Kohei Nishitani Hiromu Ito Takashi Nakamura |
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| Affiliation: | (1) Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, 606-8507 Sakyo, Kyoto, Japan |
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| Abstract: | Introduction MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma in a stable form. In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA). |
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