Search for osteoarthritis genetic markers in women with undifferentiated connective tissue dysplasia |
| |
| Authors: | R. I. Khusainova A. V. Tyurin D. A. Shapovalova E. K. Khusnutdinova |
| |
| Affiliation: | 1.Institute of Biochemistry and Genetics, Ufa Scientific Center,Russian Academy of Sciences,Ufa,Russia;2.Department of Hospital Therapy No. 2,Bashkir State Medical University,Ufa,Russia |
| |
| Abstract: | We conducted an association study of ten polymorphisms in six candidate genes of OA (rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms). |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
