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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies |
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| Authors: | Lipson Doron Capelletti Marzia Yelensky Roman Otto Geoff Parker Alex Jarosz Mirna Curran John A Balasubramanian Sohail Bloom Troy Brennan Kristina W Donahue Amy Downing Sean R Frampton Garrett M Garcia Lazaro Juhn Frank Mitchell Kathy C White Emily White Jared Zwirko Zac Peretz Tamar Nechushtan Hovav Soussan-Gutman Lior Kim Jhingook Sasaki Hidefumi Kim Hyeong Ryul Park Seung-il Ercan Dalia Sheehan Christine E Ross Jeffrey S Cronin Maureen T Jänne Pasi A Stephens Philip J |
| Institution: | Foundation Medicine, Cambridge, Massachusetts, USA. |
| Abstract: | Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET. |
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