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Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians |
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| Authors: | S Chhabra R Narang LR Krishnan S Vasisht DP Agarwal LM Srivastava SC Manchanda N Das |
| Institution: | (1) Departments of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India;(2) Department of Cardiology, All India Institute of Medical Sciences, New Delhi, 110029, India;(3) Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India;(4) Institute of Human Genetics, University of Hamburg, Hamburg, Germany;(5) Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060, India |
| Abstract: | BackgroundA close association between Sst I polymorphism in the 3' untranslated region of the apolipoproteinC3 (APOC3 ) gene and levels of plasma triglycerides (TG) had been reported by different investigators. Hypertriglyceridemia(HTG) is a known risk factor for coronary artery disease (CAD) in the context of Asian Indians. We conducted a study on the relationship between APOC3 SstI polymorphism (S1S1, S1S2 and S2S2 genotypes) and plasma TG levels in a group of 139 male healthy volunteers from Northern India. |
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