Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders |
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| Authors: | Carmen Garcí a-Ibarbia,Jesú s Delgado-Calle,Iñ igo Casafont,Javier Velasco,Jana Arozamena,Marí a I. Pé rez-Nú ñ ez,Marí a A. Alonso,Marí a T. Berciano,Fernando Ortiz,José L. Pé rez-Castrilló n,Agustí n F. Ferná ndez,Mario F. Fraga,Marí a T. Zarrabeitia,José A. Riancho |
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| Affiliation: | 1. Department of Internal Medicine, Hospital U.M. Valdecilla-IFIMAV, University of Cantabria, RETICEF, Santander, Spain;2. Department of Anatomy and Cell Biology, University of Cantabria, IFIMAV, Santander, Spain;3. Department of Orthopaedic Surgery and Traumatology, Hospital U.M. Valdecilla, Santander, Spain;4. Department of Internal Medicine, Hospital U, Rio-Hortega, University of Valladolid, Valladolid, Spain;5. Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, University of Oviedo, Oviedo, Spain;6. Unit of Legal Medicine, University of Cantabria, IFIMAV, Santander, Spain |
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| Abstract: | ![]()
We reported previously that the expression of Wnt-related genes is lower in osteoporotic hip fractures than in osteoarthritis. We aimed to confirm those results by analyzing β-catenin levels and explored potential genetic and epigenetic mechanisms involved. |
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| Keywords: | AzadC, 5-aza-2-deoxy-azacytidine CACYBP, calcyclin binding protein CAMK2G, calcium/calmodulin-dependent protein kinase II gamma CSNK1A1, casein kinase 1, alpha 1 CSNK1A1L, casein kinase 1, alpha 1-like CSNK1E, casein kinase 1, epsilon Ct, threshold cycle CTBP1, C-terminal binding protein 1 FDR, false discovery rate FOSL1, FOS-like antigen 1 FRZB, frizzled-related protein FZD10, frizzled homolog 10 GSK3B, glycogen synthase kinase 3 beta GWAS, genome-wide association study HWE, Hardy&ndash Weinberg equilibrium LRP5, lipoprotein receptor related protein 5 PLCB3, phospholipase C, beta 3 (phosphatidylinositol-specific) PPP2R1A, protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform RHOA, ras homolog gene family, member A SFRP1, secreted frizzled-related protein 1 SFRP4, secreted frizzled-related protein 4 TBL1X, transducin (beta)-like 1X-linked TBP, TATA box binding protein WNT10A, wingless-type MMTV integration site family, member 10A WNT16, wingless-type MMTV integration site family, member 16 WNT4, wingless-type MMTV integration site family, member 4 WNT8A, wingless-type MMTV integration site family, member 8A |
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