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Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder |
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| Authors: | Ali Sazci Mavi Deniz Ozel Emel Ergul Mehmet Emin Onder |
| Institution: | 1. Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380 Kocaeli, Turkey;2. Department of Psychiatry, Faculty of Medicine, University of Kocaeli, 41380 Kocaeli, Turkey |
| Abstract: | Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case–control study of 95 bipolar disorder patients and 201 healthy controls (χ2 = 13.382, P = 0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease. |
| Keywords: | PCR polymerase chain reaction PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism MTHFR methylenetetrahyrofolate reductase NNMT nicotinamide-N-methyltransferase HWE Hardy&ndash Weinberg equilibrium OR odds ratio CI confidence interval PAGE polyacrylamide gel electrophoresis |
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