No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population |
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Authors: | Guo Xia Faming Pan Fangfang Liao Xiaowu Tang Rui Ge Yang Mei Heping Pan Shengqian Xu Jianhua Xu |
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Institution: | (1) Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, China;(2) Department of Rheumatology, First Affiliated Hospital, Anhui Medical University, 230032 Hefei, China; |
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Abstract: | Ankylosing spondylitis (AS) is a rhematoid arthritis, which is a common autoimmune disease with a complex genetic etiology.
Although HLA-B27 has been identified to be associated with AS, a number of other genes may also be involved in the disease.
Fc receptor-like 3 (FCRL3) gene has been shown to be associated with rheumatoid arthritis in Japanese population. Here we
aim to explore the association FCRL3 gene and susceptibility to human leukocyte antigen (HLA)-B27-positive AS in Han Chinese
population. Among 169 AS patients, the frequencies of C and T (rs7522061) in FCRL3 gene were 38.7 and 61.3%, respectively; in 184 controls (HLA-B27-positive), the frequencies of C and T were 38.6 and 61.4%, respectively. The frequencies of alleles and genotype are not of statistically significant difference
in two groups (χ2 = 0.000, P = 0.983; χ2 = 0.099, P = 0.952, respectively),but the distribution of HLA-B27 subtypes are statistically significant difference between cases and
controls (χ2 = 8.214, P = 0.042). Our data reveal that the FCRL3 gene does not appear associated with susceptibility to HLA-B27-positive AS in Han
Chinese population. |
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