The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis |
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| Authors: | Simon Blankley Matthew Paul Reddoch Berry Christine M. Graham Chloe I. Bloom Marc Lipman Anne O'Garra |
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| Affiliation: | 1.Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK;2.Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, St Mary''s Hospital, London W2 1NY, UK;3.NHLI, Faculty of Medicine, Imperial College London, London, UK;4.Department of Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK;5.Division of Medicine, University College London, London, UK |
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| Abstract: | Despite advances in antimicrobials, vaccination and public health measures, infectious diseases remain a leading cause of morbidity and mortality worldwide. With the increase in antimicrobial resistance and the emergence of new pathogens, there remains a need for new and more accurate diagnostics, the ability to monitor adequate treatment response as well as the ability to predict prognosis for an individual. Transcriptional approaches using blood signatures have enabled a better understanding of the host response to diseases, leading not only to new avenues of basic research, but also to the identification of potential biomarkers for use in diagnosis, prognosis and treatment monitoring. |
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| Keywords: | immune response infection tuberculosis |
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