Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia root extract |
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Authors: | Shin Eun-Joo Oh Ki-Wan Kim Kee-Won Kwon Yong Soo Jhoo Jin Hyeong Jhoo Wang-Kee Cha Joo-Young Lim Yong Kwang Kim In Soon Kim Hyoung-Chun |
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Institution: | Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200-701, South Korea. |
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Abstract: | A recent investigation indicated that Polygala tenuifolia Willdenow extract (PTE) possesses a potential antipsychotic effect. In this study, we examined the effects of PTE on the cocaine-induced changes in locomotor activity, conditioned place preference (CPP), fos-related antigen-immunoreactivity (FRA-IR), and activator protein (AP)-1 DNA binding activity. Cocaine-induced behavioral effects (hyperlocomotion and CPP) occurred in parallel with increases in FRA-IR and AP-1 DNA binding activity in the nucleus accumbens. These responses induced by cocaine were consistently attenuated by concurrent treatment with PTE (25 mg or 50 mg/kg/day, i.p. x 7). The adenosine A2A receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyrl)xanthine (0.5 or 1.0 mg/kg, i.p.), reversed the PTE-mediated pharmacological action in a dose related manner; neither the adenosine A(1) receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) nor the A2B receptor antagonist, alloxazine (1.5 or 3.0 mg/kg, i.p.) significantly affected this pharmacological action. Our results suggest that PTE prevents cocaine-induced behavioral effects, at least in part, via the activation of the adenosine A2A receptor. |
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Keywords: | Polygala tenuifolia Cocaine Conditioned place preference Locomotor activity Fos-related antigen immunoreactivity Activator protein-1 DNA binding activity Nucleus accumbens Adenosine receptors |
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