Stimulation by calmodulin of Ca2+ uptake and (Ca2+-Mg2+) ATPase activity in membrane fractions from ox neurohypophyses |
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| Authors: | A.D. Conigrave M. Treiman T. Særmark N.A. Thorn |
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| Affiliation: | Institute of Medical Physiology C, University of Copenhagen Blegdamsvej 3c, DK-2200 Copenhagen N, Denmark. |
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| Abstract: | Calmodulin stimulated 45Ca2+ uptake into a plasma membrane enriched fraction from ox neurohypophysial nerve endings and into a microsome fraction. The 45Ca2+ uptake and the (Ca2+-Mg2+) ATPase activity in the plasma membrane fraction exhibited similar pCa and calmodulin sensitivities, suggesting that the enzyme activity is the biochemical expression of a high affinity Ca2+ pump. Calmodulin thus seems to play a role in regulation of the intracellular free Ca2+ concentration in the neurohypophysis. |
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| Keywords: | reprint requests to NAT. |
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