Pharmacological studies with beta-adrenoreceptor blocking agents I. Effect on the smooth muscle of the taenia coli of the guinea pig. |
| |
Authors: | V Bauer S Zakhari |
| |
Institution: | Institute of Experimental Pharmacology of Slovak Academy of Sciences, Bratislava, Czechoslovakia |
| |
Abstract: | The action of new beta-blockers of VUFB series (VUFB 6502, VUFB 8102, VUFB 8227, and trimepranol) (Fig. 1) was analyzed in smooth msucle of guinea pig taenia coli by the double sucrose-gap method. All the studied beta-blockers increased the spontaneous spike activity without changes in membrane potential. The amino-analogues (VUFB 8101, VUFB 8102, VUFB 8227) as well as practolol were found to be 50 to 100 times less active than the oxy-derivatives (VUFB 6502 and Trimepranol) for the inhibition of spike activity, muscle relaxation and membrane hyperpolarization evoked by isoprenaline. None of the studied compounds had a pronounced alpha-blocking activity. The structure-activity relationship of the studied compounds was discussed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|