| 抗菌肽抑菌机制研究进展 |
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| 引用本文： | 黄现青,高晓平,赵改名,李苗云,柳艳霞,张秋会,孙灵霞,袁勇军.抗菌肽抑菌机制研究进展[J].生物学杂志,2010,27(2):62-66. |
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| 作者姓名： | 黄现青 高晓平 赵改名 李苗云 柳艳霞 张秋会 孙灵霞 袁勇军 |
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| 作者单位： | 1. 河南农业大学食品科技学院,郑州,450002
2. 浙江万里学院生物与环境学院,宁波,315100 |
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| 摘 要： | 抗菌肽是由各种无脊椎动物、植物和哺乳动物的组织、细胞产生的丰富且分子多样性的一类物质。它们的氨基酸组成、两亲性、阳离子电荷和它们的大小使它们能够粘附或插入到细胞膜中形成孔洞,也就形成所谓的＂木桶式＂、＂地毯式＂和＂环孔式＂的机制。主要介绍几种不同的诱导细菌孔洞形成、细胞死亡的模型及耐药机制。
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| 关 键 词： | 抗菌肽 机制 孔洞 |
Review of bacteriostasis mechanisms of antimicrobial peptides |
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| HUANG Xian-qing,GAO Xiao-ping,ZHAO Gai-ming,LI Miao-yun,LIU Yan-xia,ZHANG Qiu-hui,SUN Ling-xia,YUAN Yong-jun.Review of bacteriostasis mechanisms of antimicrobial peptides[J].Journal of Biology,2010,27(2):62-66. |
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| Authors: | HUANG Xian-qing GAO Xiao-ping ZHAO Gai-ming LI Miao-yun LIU Yan-xia ZHANG Qiu-hui SUN Ling-xia YUAN Yong-jun |
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| Institution: | HUANG Xian-qing1,GAO Xiao-ping1,ZHAO Gai-ming1,LI Miao-yun1,LIU Yan-xia1,ZHANG Qiu-hui1,SUN Ling-xia1,YUAN Yong-jun2(1.College of Food Science , Technology,Henan Agriculture University,Zhengzhou 450002,2.College of Biology , Environment,College of Zhejiang Wanly,Ningbo 315100,China) |
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| Abstract: | Antimicrobial peptides are an abundant and diverse group of molecules.They are produced by many tissues and cell types in a variety of invertebrate,plant and animal species.Their amino acid composition,amphipathicity,cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by barrel-stave',carpet' or toroidal-pore' mechanisms.The different models of antimicrobial-peptide-induced pore formation and cell killing and drug-fast mechanisms were presented in this review. |
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| Keywords: | antimicrobial peptides mechanisms pores |
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